GoDubai
  
  
  
  
Citylife > Press Release
  Home Contact us Add to Favourites
Most Recent Postings
More Press Releses
Featured Sections

Event Finder
A daily roundup of exhibitions, promotions and other events in Dubai and the rest of the Emirates.
Submit an Event
Latest Dubai Press Releases >>

 
  Share
  • New findings are published in the journal Chemical Science
  • “There is significant promise for developing new cancer therapies that can complement the existing chemotherapy options that are currently used to treat nearly half of all cancer patients undergoing chemotherapy,” explains Ali Trabolsi

Abu Dhabi, May 23, 2019:  Researchers from NYU Abu Dhabi's (NYUAD) chemistry program and colleagues from the University's biology program have developed and studied the biological activity of five new, metal-organic hybrid knotted molecules, termed metal-organic trefoil knots (M-TKs). These molecules can effectively deliver metals to cancer cells, demonstrating the potential to act as a new category of anti-cancer agents. 

In a study published in the journal Chemical Science, NYUAD Research Scientists Farah Benyettou and Thirumurugan Prakasam from the Trabolsi Research Group, led by NYUAD Associate Professor of Chemistry Ali Trabolsi, report that these nanoscale, water-soluble M-TKs showed high potency in vitro against six cancer cell lines and in vivo in zebrafish embryos. Zebrafish-related studies were performed by NYUAD Postdoctoral Associate Anjana Ramdas Nair from the Sadler Lab.

The M-TKs, generated by metal-templated self-assembly of a simple pair of chelating ligands, were well tolerated in vitro by non-cancer cells but were significantly more potent than cisplatin, a common chemotherapy medication, in both human cancer cells––including those that were cisplatin-resistant––and in zebrafish embryos. In cultured cells, M-TKs introduce reactive oxygen species (ROS) that damage the mitochondria of cancer cells, but not the nuclear DNA or the plasma membrane. 

“The cytotoxicity and wide scope for structural variation of M-TKs indicate the potential of synthetic metal-organic knots as a new field of chemical space for pharmaceutical design and development,” said Trabolsi. “There is significant promise for developing new cancer therapies that can complement the existing chemotherapy options that are currently used to treat nearly half of all cancer patients undergoing chemotherapy.”

Benyettou said, “The M-TKs synthesized by NYUAD Research Scientist Thirumurugan Prakasam from the Trabolsi Research Group were found, in many cases, to have greater potency than has been previously reported in cisplatin and other metal complexes, explains NYUAD Research.” 

“The main delivery routes were macropinocytosis and both caveolin- and clathrin-mediated endocytosis, which are all more active in cancer cells than in normal cells. Cisplatin and other small molecules penetrate cells by diffusion, which is less cancer-selective in vitro. The researchers hypothesize that the molecules they have developed are less toxic to healthy cells because they are internalized less,” added Benyettou.

In the next stage of developing M-TKs,  research efforts will focus on the mechanism of action of the M-TKs to determine whether their ROS-mediated toxicity involves specific intracellular targets.

These findings confirm the viability of studying the effects of these compounds in whole vertebrates, as the M-TKs were well tolerated by zebrafish and appeared to selectively attack dividing cells. 

Other NYUAD collaborators include fourth year graduate PhD student Tina Skorjanc, who contributed to the paper's biological-related aspects. 

The research was carried out using the Core Technology Platform resources at NYUAD, which are shared facilities that support research activities across disciplines. 



Posted by : GoDubai Editorial Team
Viewed 4508 times
Posted on : Thursday, May 23, 2019  
Replication or redistribution in whole or in part is expressly prohibited without the prior written consent of GoDubai.com.
Previous Story : Repton, Abu Dhabi's iftar marks International Day of Families
Next Story : Dubai Cares successfully wraps up its Ramadan volunteering initiative with the participation of 2,00...
Email this article Print this article

Share this article with your friends and followers
NewsVine

Comments

Back to Top  
Most Viewed Press Release posted in the last 7 days
Hackket's Bags of Style
Tissot Introduces Chrono XL 3x3 Street Basketball Special Collection
Introducing the Swim and Beachwear Summer Collection from Marks & Spencer
Saint Honore
Chloé Launches The New Cloud-shaped “rosie” Sunglasses
BYS COSMETICS Now in UAE
VBQ-presskit-denim-70s Capsule
New Land Rover Defender Completes Tusk Testing to Support Lion Conservation in Kenya
OMEGA Rocket Engine - Introducing the Master Chronometer Calibre 3861
Ministry of State for FNC Affairs Launches Forum Titled ‘Political Empowerment i...
Natural and gentle haircare essentials for your little ones from Fifi & Friends'
Electricity Most Searched Fuel Energy Term Online in UAE
Eberhard & Co. Alfa Romeo Limited Edition
Jaguar Land Rover & Bmw Group Announce Collaboration for Next Generation Electri...
Rado Captain Cook Automatic Limited Edition with travel case'
Britain's Greatest Test Driver, Norman Dewis Obe, Passes Away
From the Big Screen to Real Life: Tag Heuer Unveils New Monaco Limited Edition ...
Aston Martin Produces First Cars at St Athan
The Gucci Runway Makeup Looks for Cruise 2020
BMW Group and Jaguar Land Rover announce collaboration for next-generation elect...
Kickstart your summer workout with Ibn Battuta Mall's free indoor family Fun Run
Vincitore Realty sells out 108 homes in the Dh375 million Benessere project in j...
Certina DS PH200M collection'
Backseat battles: kids driving their parents to distraction – and danger on the ...
Sony World Photography Awards Reveals New Categories for 2020 and Latest Sony Gr...
The Chaumet Garden of Earthly Delights
UAE and Oman bodies sign MoU to jointly promote Internal Auditing
Choose the perfect fragrance this Father's Day with Rasasi
ZAAM Launches a spin on their iconic Polyhedron bag
Jaquet Droz Unveils Its 2019 Novelties at Dubai Mall
Jennifer Lopez in Ralph Lauren
The SS19 Exclusive Edit From Etoile “La Boutique''
Happy Father's Day with Tonda 1950 Skeleton
Ferragramo Cuir
Restoration by Parmigiani Fleurier
Empower launches summer campaign to reduce district cooling consumption for the ...
Dubai Cares supports 3-year teacher training program in Ghana to boost early chi...
Team Abu Dhabi award Cappellini new long-term contract
Celebrate Father's Day with Marks & Spencer
Dp World, UAE Region's Strategic Solutions Boost the Automotive Sector
Hamilton present Ventura collection
Eberhard & Co. Alfa Romeo Limited Edition'
Introducing the MK Beach Club Pieces
Sharjah Department of Statistics and Community Development Calls on Citizens to ...
Aston Martin Ready to Race in the Spirit of '59 as It Honours 60th Anniversary L...
Lukoil Marine Lubricants strengthens its collaboration with KOTC
La Grande Vie by Corum
Turkish Airlines added Strasbourg to the list of its destinations in France
AMD and Samsung Announce Strategic Partnership in Ultra Low Power, High Performa...
The Health & Hygiene Industry Rises in MBLM's 2019 Brand Intimacy Study and is t...