GoDubai
  
  
  
  
Citylife > Press Release
  Home Contact us Add to Favourites
Most Recent Postings
More Press Releses
Featured Sections

Event Finder
A daily roundup of exhibitions, promotions and other events in Dubai and the rest of the Emirates.
Submit an Event
Latest Dubai Press Releases >>

 
  Share
The liver is the only solid organ that can regenerate itself in mammals, but what confers this special property to the liver has not been uncovered, despite decades of research.
● NYU Abu Dhabi researchers suggest that a novel mechanism driven by the epigenome promotes liver regeneration.
● The epigenome refers to the code that packages the DNA so that some parts can be activated (i.e. genes) and some parts remain in dormant domains - these dormant parts largely contain remnants of old viruses or transposable elements.
● Epigenetic compensation is when parts of the epigenome that usually have one role - i.e. to suppress genes, are co-opted to do a different job - when another part of the epigenome is missing modifications in the packaging material of the DNA influence how much a genetic program is active or repressed. These modifications do not change the DNA sequence, but instead, affect how cells read genes.
● This study reports that the primary role of the epigenome is to protect the genome against the activation of genomic parasites (transposable elements).
● The new findings have been published in the journal Developmental Cell.
 
Abu Dhabi, June 22, 2019:  In a recent study published in the journal Developmental Cell, NYU Abu Dhabi researchers have reported a new way in which the liver is primed to regenerate itself. They found that by stripping parts of the epigenome, which play a primary role in repressing “jumping genes” (i.e. transposable elements), other epigenetic marks were redistributed.
 
This newly discovered form of epigenetic compensation protects the genome against transposable elements activation, but takes these compensating epigenetic marks away from their normal job in regulating gene expression. The result is that when these marks are taken away from their normal role, the genes they usually repress are activated early and are sustained during the regenerative response to the surgical removal of part of the liver.
 
This type of surgery is relevant to humans, as it is used in resection of liver tumors and the regenerative response is essential for the liver to respond to damage. The findings are a significant advance in the understanding of the liver regeneration process, which is unique among the organs of humans, mice, and other mammals.
 
The researchers from NYU Abu Dhabi's Sadler Lab, led by Associate Professor of Biology Kirsten Sadler Edepli, removed a key epigenetic regulator, UHRF1 in the mouse liver. They found when they removed part of the liver, the remaining lobes responded more readily by activating pro-regenerative genes activated earlier, and this regeneration program stayed active longer, resulting in enhanced liver regeneration.
 
The epigenome refers to the code that packages the genome so that some parts can be activated (i.e. genes) and some parts remain in dormant domains - these dormant parts largely contain remnants of old viruses or transposable elements, which were made famous by the 1983 Nobel Prize discovery by Barbara McClintok.
 
Surprisingly, instead of causing massive activation of transposable elements or an immune response to mitigate the unleashing of transposable elements, as found in previous experiments, they discovered that there is an extra layer of protection by another repressive epigenetic mark (H3K27me3). This mark was redistributed from gene promoters to suppress transposable elements when DNA methylation was missing, thereby compensating for the loss of DNA methylation. When this mark is redistributed, it is removed from its role in repressing genes that promote liver regeneration. Thus, livers lacking UHRF1 are able to regenerate faster.
 
“When H3K27me3 compensates for the loss of DNA methylation, this results in a favorable epigenetic environment for liver regeneration,” said Sadler Edepli. “It will be exciting to explore whether drugs that can modify the epigenome have the potential to induce epigenetic compensation and increase the liver's ability to regenerate in cases of liver disease or failure.” Shuang Wang, a post-doctoral fellow in the Sadler Edepli laboratory who worked in her group at Icahn School of Medicine at Mount Sinai, led the study in collaboration with members of the lab at NYUAD as well as Emily Bernstein and Amaia Lujambio in NY.



Posted by : GoDubai Editorial Team
Viewed 9852 times
Posted on : Saturday, June 22, 2019  
Replication or redistribution in whole or in part is expressly prohibited without the prior written consent of GoDubai.com.
Previous Story : Millennials' Naturally Leading the Wellness Journey
Next Story : Cook Children's guidelines on How to Protect Your Kids from the Summer Heat
Email this article Print this article

Share this article with your friends and followers
NewsVine

Comments

Back to Top  
Most Viewed Press Release posted in the last 7 days
A touch of elegance with Al Asel
Introducing Pestle & Mortar
Glamorous Gilda for elegant lady'
The art of knurling
Tag Heuer Launches Limited Edition Green Aquaracer in the Kingdom of Saudi Arabi...
Nikon ME Launches Film Festival - Cinema Z
Titan Watches unveils new ‘Create Your Moment' campaign
Versus Saint Germain
Protect your Hair with the New Hair Care Range from Color WOW.
CORUM announces Hu Bing as its new Global Brand Ambassador
Compact, yet spacious, Kia Pegas sedan to be sold in the UAE for the first time
Admiral AC-One 45 Chronograph Bronze
Union Coop Signs a contract with AL Aber contracting to construct Umm Al Quwain ...
Midi Moment
As Official Timekeeper of the 2020 IIHF Ice Hockey World Championship, Tissot st...
Burberry Beauty reveals its runway make-up look, inspired by the September 2020 show
Beauty beyond time OMEGA's fine jewellery collection
Skin Care+ an Intensely Nourishing Range
General Civil Aviation Authority launches 2nd edition of Global Investment in Av...
Epson partners with Tenaui to participate in Xposure photography festival
Al Yousuf Motors hosts the UAE debut of the new MG5
Spring/Summer 2020
'Al Wahda Mall to welcome THE DEAL'
UAE-based investors to develop 5 Economic Zones in Bangladesh
Planetarium show by Lulu Group at Mushrif Mall this weekend
Epson launches world's smallest 3LCD laser projector in the region
GITEX Technology Week and GITEX Future Stars to show how next-gen technologies a...
Bee My Love – Cocktail Rings
Redtag's ‘just My Mood' Sleepwear Collection
Twelve Majid Al Futtaim shopping malls to participate in 11th annual ‘Feel the B...
MoHAP Organizes in Cooperation with Majid Al Futtaim an Awareness Campaign on th...
Emirates Steel to participate in the first Saudi International Iron & Steel Conf...
Year of Tolerance Art Exhibition by 2XL Furniture & Home Décor Opens with a Gran...
Mintsa: Successfully launching in the UAE
UAE investors set to inject US$10 billion into Bangladesh economy
Turkish Airlines named 2020 Five Star Global Airline at APEX Awards
Dubai FDI delegation promotes Dubai in Denver
BMW at the IAA Cars 2019 in Frankfurt
Al Qemzi Keeps Team Abu Dhabi on Course for Quadruple World Title Success
The Rack by Kachins Presents PS20
The Trench Coat and Mac Edit
Educational Events of Mohammed bin Rashid Space Centre (MBRSC) and Japan Aerospa...
GEMS Education finds a way on how to effectively prepare when your child flees t...
Ginger signs a new hotel in Candolim, GOA
Nursery to go paperless for a week as a mark of respect to the burning Amazon
Saxophone night with a view!
ENEC and TENEX renew MoU
Materials Handling Middle East racks up 12% visitor turnout for 10th edition
October Specials at Le Meridien al Aqah
GEMS Cambridge International Private School Sharjah welcomes 840 students and 60...