GoDubai
  
  
  
  
Citylife > Press Release
  Home Contact us Add to Favourites
Most Recent Postings
More Press Releses
Featured Sections

Event Finder
A daily roundup of exhibitions, promotions and other events in Dubai and the rest of the Emirates.
Submit an Event
Latest Dubai Press Releases >>

 
  Share
The liver is the only solid organ that can regenerate itself in mammals, but what confers this special property to the liver has not been uncovered, despite decades of research.
● NYU Abu Dhabi researchers suggest that a novel mechanism driven by the epigenome promotes liver regeneration.
● The epigenome refers to the code that packages the DNA so that some parts can be activated (i.e. genes) and some parts remain in dormant domains - these dormant parts largely contain remnants of old viruses or transposable elements.
● Epigenetic compensation is when parts of the epigenome that usually have one role - i.e. to suppress genes, are co-opted to do a different job - when another part of the epigenome is missing modifications in the packaging material of the DNA influence how much a genetic program is active or repressed. These modifications do not change the DNA sequence, but instead, affect how cells read genes.
● This study reports that the primary role of the epigenome is to protect the genome against the activation of genomic parasites (transposable elements).
● The new findings have been published in the journal Developmental Cell.
 
Abu Dhabi, June 22, 2019:  In a recent study published in the journal Developmental Cell, NYU Abu Dhabi researchers have reported a new way in which the liver is primed to regenerate itself. They found that by stripping parts of the epigenome, which play a primary role in repressing “jumping genes” (i.e. transposable elements), other epigenetic marks were redistributed.
 
This newly discovered form of epigenetic compensation protects the genome against transposable elements activation, but takes these compensating epigenetic marks away from their normal job in regulating gene expression. The result is that when these marks are taken away from their normal role, the genes they usually repress are activated early and are sustained during the regenerative response to the surgical removal of part of the liver.
 
This type of surgery is relevant to humans, as it is used in resection of liver tumors and the regenerative response is essential for the liver to respond to damage. The findings are a significant advance in the understanding of the liver regeneration process, which is unique among the organs of humans, mice, and other mammals.
 
The researchers from NYU Abu Dhabi's Sadler Lab, led by Associate Professor of Biology Kirsten Sadler Edepli, removed a key epigenetic regulator, UHRF1 in the mouse liver. They found when they removed part of the liver, the remaining lobes responded more readily by activating pro-regenerative genes activated earlier, and this regeneration program stayed active longer, resulting in enhanced liver regeneration.
 
The epigenome refers to the code that packages the genome so that some parts can be activated (i.e. genes) and some parts remain in dormant domains - these dormant parts largely contain remnants of old viruses or transposable elements, which were made famous by the 1983 Nobel Prize discovery by Barbara McClintok.
 
Surprisingly, instead of causing massive activation of transposable elements or an immune response to mitigate the unleashing of transposable elements, as found in previous experiments, they discovered that there is an extra layer of protection by another repressive epigenetic mark (H3K27me3). This mark was redistributed from gene promoters to suppress transposable elements when DNA methylation was missing, thereby compensating for the loss of DNA methylation. When this mark is redistributed, it is removed from its role in repressing genes that promote liver regeneration. Thus, livers lacking UHRF1 are able to regenerate faster.
 
“When H3K27me3 compensates for the loss of DNA methylation, this results in a favorable epigenetic environment for liver regeneration,” said Sadler Edepli. “It will be exciting to explore whether drugs that can modify the epigenome have the potential to induce epigenetic compensation and increase the liver's ability to regenerate in cases of liver disease or failure.” Shuang Wang, a post-doctoral fellow in the Sadler Edepli laboratory who worked in her group at Icahn School of Medicine at Mount Sinai, led the study in collaboration with members of the lab at NYUAD as well as Emily Bernstein and Amaia Lujambio in NY.



Posted by : GoDubai Editorial Team
Viewed 6545 times
Posted on : Saturday, June 22, 2019  
Replication or redistribution in whole or in part is expressly prohibited without the prior written consent of GoDubai.com.
Previous Story : Millennials' Naturally Leading the Wellness Journey
Next Story : Cook Children's guidelines on How to Protect Your Kids from the Summer Heat
Email this article Print this article

Share this article with your friends and followers
NewsVine

Comments

Back to Top  
Most Viewed Press Release posted in the last 7 days
Tonda 1950 Stone-set range'
Parmigiani Fleurier Kalpagraphe Chronometre Titanium
Colourful Anniversary Limited anniversary edition now available in new colors
Toric Hémisphères Rétrograde Slate The traveller's watch featuring a new guilloc...
Special edition 2019 Ford Expedition ‘Turath' arrives in Al Tayer Motors and Pre...
Aston Martin Valkyrie Wows Crowds on Public Debut at Silverstone
Sports Collection - Autumn Winter 2019
Salvatore Ferragamo Timepieces – Summer 2019 Collection
Happy Eid with Corum Golden Bridge Round 39
Picnic Indoors This Summer with Marks & Spencer
The inauguration of codeshare flights between Kuwait and Istanbul-Sabiha Gö...
Kitchen Hacks: 8 Clever Ways to Smart Storing
Tissot Heritage 1973 The racing legacy
Ralph Lauren at The Championships, Wimbledon – Wednesday 10th July
Schneider Electric's Biggest Engineer-to-Order Factory in Asia Utilizes IIoT Tec...
The Perfect Shave Kit for your Summer Travels
Ralph Lauren at The Championships, Wimbledon – Sunday 14th July
Summer Skin Rituals with SUKIN
Peugeot announces sizzling summer offers
Union Coop Reports 20% Growth in Net Profit for the First half of 2019
Dubai's leading school operator to launch Affordable IB School in Dubai- Ambassa...
Ride Into the New School Year with the Coolest Gear
IHG signs world's largest voco with Maad International in Saudi Arabia
Summer-ready BABY-G G-Lide BAX-100 makes splash this hot season
FW 2019 Amazone'
Robotics and Automation to the Fore at Materials Handling Middle East
Empower launches “Intelligent Delta- T Analyzer and Detector”
Purificacion Garcia Introduces the Women's FW19 Collection
Ras Al Khaimah and Singapore to Discuss the Bilateral Cooperation'
Dubai Duty Free and Arabian Automobiles raffle a Nissan GT-R this holiday season
Philipsen and Kristoff Claim Top 10 Spots for Uae Team Emirates in Stage 7 Sprin...
Automation Anywhere Expands into the Middle East with the Opening of Regional He...
The Car That Responds to Your Mood: New Jaguar Land Rover Tech Helps Reduce Stress
Union Coop Releases ‘First' Update of Its Electronic Share Trading Platform
Al Qutami chairs DHA CEO council meeting
All-out Sprint in Albi as Philipsen Takes Sixth and Martin Breaks Into the Gener...
OMEGA's role in competitive swimming
Canadian University Dubai joins Silk-Road Universities Network
Ahmed Mahboob Musabih welcomes DGEP Coordinator General
Etihad Airways Recommences Flights to Khartoum
Schneider Electric Launches First Smart Factory in Mexico Implementing Innovativ...
Dubai International Financial Centre Continues to Prioritise Ease of Doing Busin...
Bollywood Parks™ Dubai launches all-inclusive picnic promotion from July to August
First results from Arc Skills' programme show how gamification can transform edu...
Lg's Front-loader With New Ai Dd Brings Optimized Washing to the Middle East and...
MoHAP Youth Council Discusses Mutual Cooperation with Civil Defence Youth Council
A charitable initiative from the ADNOC Sas Al Nakhl School brings together AED 8...
Emirates' US-bound passengers soon to have Wi-Fi, mobile connectivity and Live T...
Don't Run Risk of Damaging Your Vision With Poor Food Choices, Doctors at Moorfi...
Pottery Barn Kids launches new ‘Back-to-School' collection'