GoDubai
  
  
  
  
Citylife > Press Release
  Home Contact us Add to Favourites
Most Recent Postings
More Press Releses
Featured Sections

Event Finder
A daily roundup of exhibitions, promotions and other events in Dubai and the rest of the Emirates.
Submit an Event
Latest Dubai Press Releases >> Healthcare and Medicine

 
  Share
The liver is the only solid organ that can regenerate itself in mammals, but what confers this special property to the liver has not been uncovered, despite decades of research.
● NYU Abu Dhabi researchers suggest that a novel mechanism driven by the epigenome promotes liver regeneration.
● The epigenome refers to the code that packages the DNA so that some parts can be activated (i.e. genes) and some parts remain in dormant domains - these dormant parts largely contain remnants of old viruses or transposable elements.
● Epigenetic compensation is when parts of the epigenome that usually have one role - i.e. to suppress genes, are co-opted to do a different job - when another part of the epigenome is missing modifications in the packaging material of the DNA influence how much a genetic program is active or repressed. These modifications do not change the DNA sequence, but instead, affect how cells read genes.
● This study reports that the primary role of the epigenome is to protect the genome against the activation of genomic parasites (transposable elements).
● The new findings have been published in the journal Developmental Cell.
 
Abu Dhabi, June 22, 2019:  In a recent study published in the journal Developmental Cell, NYU Abu Dhabi researchers have reported a new way in which the liver is primed to regenerate itself. They found that by stripping parts of the epigenome, which play a primary role in repressing “jumping genes” (i.e. transposable elements), other epigenetic marks were redistributed.
 
This newly discovered form of epigenetic compensation protects the genome against transposable elements activation, but takes these compensating epigenetic marks away from their normal job in regulating gene expression. The result is that when these marks are taken away from their normal role, the genes they usually repress are activated early and are sustained during the regenerative response to the surgical removal of part of the liver.
 
This type of surgery is relevant to humans, as it is used in resection of liver tumors and the regenerative response is essential for the liver to respond to damage. The findings are a significant advance in the understanding of the liver regeneration process, which is unique among the organs of humans, mice, and other mammals.
 
The researchers from NYU Abu Dhabi's Sadler Lab, led by Associate Professor of Biology Kirsten Sadler Edepli, removed a key epigenetic regulator, UHRF1 in the mouse liver. They found when they removed part of the liver, the remaining lobes responded more readily by activating pro-regenerative genes activated earlier, and this regeneration program stayed active longer, resulting in enhanced liver regeneration.
 
The epigenome refers to the code that packages the genome so that some parts can be activated (i.e. genes) and some parts remain in dormant domains - these dormant parts largely contain remnants of old viruses or transposable elements, which were made famous by the 1983 Nobel Prize discovery by Barbara McClintok.
 
Surprisingly, instead of causing massive activation of transposable elements or an immune response to mitigate the unleashing of transposable elements, as found in previous experiments, they discovered that there is an extra layer of protection by another repressive epigenetic mark (H3K27me3). This mark was redistributed from gene promoters to suppress transposable elements when DNA methylation was missing, thereby compensating for the loss of DNA methylation. When this mark is redistributed, it is removed from its role in repressing genes that promote liver regeneration. Thus, livers lacking UHRF1 are able to regenerate faster.
 
“When H3K27me3 compensates for the loss of DNA methylation, this results in a favorable epigenetic environment for liver regeneration,” said Sadler Edepli. “It will be exciting to explore whether drugs that can modify the epigenome have the potential to induce epigenetic compensation and increase the liver's ability to regenerate in cases of liver disease or failure.” Shuang Wang, a post-doctoral fellow in the Sadler Edepli laboratory who worked in her group at Icahn School of Medicine at Mount Sinai, led the study in collaboration with members of the lab at NYUAD as well as Emily Bernstein and Amaia Lujambio in NY.



Posted by : GoDubai Editorial Team
Viewed 6100 times
Posted on : Saturday, June 22, 2019  
Replication or redistribution in whole or in part is expressly prohibited without the prior written consent of GoDubai.com.
Previous Story : Ministry of Health & Prevention Unveils the Largest Expansion of Medical Examination Centers to Reac...
Next Story : RAK Hospital receives Superbrands Award for the fifth time
Email this article Print this article

Share this article with your friends and followers
NewsVine

Comments

Back to Top  
Most Viewed Press Release posted in the last 7 days
T-Race Cycling Tour de France The Watch for Fans of Le Tour
Ink Your Lips This Summer With Artist Rouge Ink, Make Up for Ever's New Airlight...
Tonda 1950 Stone-set range'
Ermanno Scervino, The Perfume
Transform Your Bedroom and Sleep Like a King With Robinsons' Latest Bedlinen Col...
Siemens to supply power equipment and services for 840 MW power plant in Iraq
Faces launches Next Generation stores in Mall of the Emirates, Dubai and Riyadh ...
Computer & Power Technology Adds Cisco Collaborate Architecture Award to its Lis...
Colourful Anniversary Limited anniversary edition now available in new colors
Contract signed: BMW Group and Daimler AG launch long-term development cooperati...
The Network Gets Smarter, Simpler and More Secure with Artificial Intelligence a...
3 ways to give your hair the power of plants, with 3 new highly concentrated hai...
Parmigiani Fleurier Kalpagraphe Chronometre Titanium
Salvatore Ferragamo Presents Minuetto
Back to School with Marks & Spencer
Happy Eid with Corum Golden Bridge Round 39
Statement Handbags from GUESS
DP Haute Joaillerie thématique 2019 – Les Ciels de Chaumet
Aston Martin Valkyrie Wows Crowds on Public Debut at Silverstone
Dubai-based Blue Ocean Group expands into UK distribution market ahead of Brexit
Mouawad unveils the Mouawad Dragon Yellow and White Diamond Suite, featuring the...
The inauguration of codeshare flights between Kuwait and Istanbul-Sabiha Gö...
Schneider Electric's Biggest Engineer-to-Order Factory in Asia Utilizes IIoT Tec...
Special edition 2019 Ford Expedition ‘Turath' arrives in Al Tayer Motors and Pre...
Ralph Lauren at The Championships, Wimbledon – Wednesday 10th July
Tissot Heritage 1973 The racing legacy
Toric Hémisphères Rétrograde Slate The traveller's watch featuring a new guilloc...
Samsung QLED 8K: How AI Upscaling Enables Truly Immersive Picture & Sound
‘Legislative Needs Forum' discusses key elements of ‘Legislative Plan 2020' in l...
Spring Summer 2020 Collection
A Sensational Summer for Shoppers: Win a Water's Edge Apartment Worth Aed 1 Mill...
Abu Dhabi Health Services Company (SEHA) implements smart pharmacy systems to im...
Dubai Customs explores more mutual trade with KSA
If the Shoe Fits
Celebrated singer and composer Quratulain Balouch set to perform at Rajmahal The...
Sports Collection - Autumn Winter 2019
Ahmad Daham becomes first Arab drifter to participate in Drift Masters European ...
Union Coop Reports 20% Growth in Net Profit for the First half of 2019
Ride Into the New School Year with the Coolest Gear
MoHAP Youth Council Interviews Zainab Al Bloushi “Winner of Happiness and Positi...
The Perfect Shave Kit for your Summer Travels
IHG signs world's largest voco with Maad International in Saudi Arabia
Dubai's leading school operator to launch Affordable IB School in Dubai- Ambassa...
GUESS - Floral Print
Corporations' long-term success hinges on their business model supporting humani...
Lincoln Nautilus: Luxury Redefined Inside and Out
The 5G era begins: Huawei launches the King of 5G smartphones HUAWEI Mate 20 X (5G)
Ajman Bank Launches New Branch in Dalma Mall and with it Introduces Another Digi...
Celebrities in Ralph Lauren at the 2019 Vogue Paris Foundation Gala
Robotics and Automation to the Fore at Materials Handling Middle East